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Qiuyun Chen
 
Professor
Ph.D., Nanjing University, 2001
M.S., Sichuan University, 1990
B.S., Anhui Normal University, 1987
 
School of Chemistry and Chemical Engineering
Jiangsu University
Zhenjiang, Jiangsu 212013, P.R. China
E-mail: chenqy@ujs.edu.cn

                 
Research fields:
Research in the Chen group is focused on two major areas: chemical biology and bioinorganic chemistry.
Chemical Probes for Discovery and Imaging of Biological Processes in Living Cells and Animals. Compared to conventional biological methods, chemical probes offer a precise and powerful approach to study biology at the cellular and organism level with minimal perturbation to the intact native system. We are developing new chemical tools for real-time monitoring of metals, metabolites, and enzyme activities in living cells using small-molecule fluorescent sensors. The development of functional optical imaging, bioluminescent protein, and magnetic resonance imaging (MRI) contrast agents for in vivo imaging in living animals is also being pursued.
Redox Biology in Cancer. Reactive oxygen species (ROS) like hydrogen peroxide are conventionally viewed as phagocytic killing agents of pathogens in immune response or as contributors to oxidative stress and inflammation events associated with aging and diseases ranging from cancer to diabetes to heart disease. However, newly emerging data suggests that hydrogen peroxide can also be an essential component of normal signal transduction cascades. We are studying the attenuation on the signaling of hydrogen peroxide and related ROS and their effects on the growth, proliferation, differentiation, and migration of cancer tumor cells and stem cells relevant to anti-tumor chemotherapeutics and regenerative medicine.
Energy Catalysis and Green Chemistry. The development of new catalysts that allow efficient energy storage and release in the form of chemical fuels is essential to meeting this ultimate goal. In this context, we are pursuing fundamental synthetic and physical inorganic chemistry to prepare and characterize new coordination complexes with reduced environmental impact that utilize cheap and earth-abundant metals. These metal complexes are being applied to develop stoichiometric and catalytic reactions towards water, oxygen and related small molecules of energy consequence that work in benign solvents like water. We are also exploring fundamental aspects of metal-ligand multiple bonding and small-molecule activation using first- and/or second-sphere coordination chemistry approaches.
 
Published Papers:
1 Yang X, Chen QY, Kong MY, Qu LL, Geng ZR, Wang ZL, An ionic liquid-modified nano-vehicle to construct nano-models of catalase to target mitochondria, J. Mater. Chem.2012, 22, 95,20299-20304.
2 Tao GP, Chen QY, Yang X, Wang KY, A core-shell silica nanosphere for the offeon chemosensor of iron(III) ions and the targeted probe for optical imaging on HeLa cells, Dyes Pigments 2012,  338-343.
3 Yang X, Chen QY, Li X, Gao J. Functional ionic liquids induced the formation of mitochondria targeted fluorescent core–shell ellipsoidal nanoparticles with  anticancer properties, Colloids Surf. B: Biointer. 2012, 98, 91-96.
4 Chen QY, Tao GP, Liu YQ, Yang X, Synthesis, characterization, cell imaging and anti-tumor activity of multifunctional nanoparticles, Spectrachim. Acta A: 2012, 96: 284-288.
6 Yang X, Chen QY, Song JB, Tumor-imaging core-shell nano-models for catalase, Chin. Inorg. Chem. 2012, 128, 164-170.
7 Chen QY, Fu HJ, Zhu WH, Qi Y, Ma ZP, Zhao KD , Gao J , Interaction with DNA and different effect on the nucleus of cancer cells for copper(II) complexes of N-benzyl di(pyridylmethyl)amine Dalton Trans., 2011, 40, 4414–4420.
8 Zhou DF, Chen QY, Qi Y, Fu HJ, Li Z, Zhao KD, Gao J, Anticancer Activity, Attenuation on the Absorption of Calcium in Mitochondria and Catalase Activity for Manganese complexes of N-substituted di(picolyl)amine, Inorg. Chem., 2011, 50, 6929-6937.
9 Zhou DF, Chen QY, Fu HJ, Qi Y, The formation of a luminescent Mn(III, IV)  intermediate of bis(2-pyridylmethyl)amine and acetone assistant its intramolecular C-H oxidation, Spectrochim. Acta Part A, 2011, 81, 604-608.
10 Tao GP, Chen QY, Yang X,  Zhao KD, Gao J, Targeting cancer cells through iron(III) complexes of di(picolyl)amine modified silica core–shell nanospheres, Colloids Surf. B: Biointer. 2011, 86:106–110.
11 Guo WJ, Ye SS, Cao N , Huang JA , Gao J, Chen QY, ROS-mediated autophagy was involved in cancer cell death induced by novel copper(II) complex, Exp. Toxi. Pathol.  2010, 62 (5), 577-582 .
12 Chen QY, Zhou DF, Huang J, Guo WJ, Gao J, Synthesis, anticancer activities, interaction with DNA and mitochondria of manganese complexes, J. Inorg. Biochem., 2010,  104, 1141-1149.
13 Chen QY, Wang LY, Zhang LR, Guo WJ, Gao J, Targeting cancer cells through Mn(II)–dpa grafted silica nanoparticles, Sci. Chin. Chem. 2010, 53(8): 1728-1732. 
14  Li B, Chen QY, Wang YC, Huang J, Li Y, Synthesis, characterization and fluorescence studies of a novel europium complex based sensor, J. Lumin. 2010, 130: 2413-2417.
 
 
 
 
 
 
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